Atopic dermatitis (AD) is an inflammatory skin disease causing itching and redness. CGRP (calcitonin gene-related peptide) is a neuropeptide that plays an important role in pain and inflammation. Recent studies have suggested that CGRP may be involved in the pathogenesis of atopic dermatitis. Indeed, an increase in CGRP expression has been observed in skin with atopic dermatitis compared to healthy skin. In addition, administration of antibodies directed against CGRP has been shown to improve the symptoms of atopic dermatitis in some patients.

These results suggest that CGRP may play a role in regulating the immune response and skin inflammation associated with atopic dermatitis. However, further research is needed to develop potential treatments based on this pathway.

Severe atopic dermatitis as well as other skin diseases may also involve ciguatoxins, which are found in some fish and cause ciguatera food poisoning. They can activate CGRP release. It emphasizes the need to understand these processes to develop effective treatments.

In this application note, discover how the Bertin Bioreagent ELISA CGRP kit was used to accurately evaluate CGRP release in mouse and rat skin preparations induced by ciguatoxins. This method has helped to better understand the underlying mechanisms of ciguatera intoxication and may also aid in identifying new therapeutic targets for skin diseases, such as Atopic Dermatitis.

Read the application note