Introduction
The development of new vaccines and drugs often requires an emulsion step prior to injection. This is also the case of autoimmune diseases and immunotherapy treatments for cancer. In these approaches, the emulsion step is key to the experiment success. For example, to induce disease in the human models for Multiple Sclerosis (EAE) and Rheumatoid Arthritis (CIA), emulsions must be water-in-oil, stable and particle size should be homogenous. Unfortunately, current methods to prepare emulsions have several limitations, among which:
-
- Reproducibility: high quality emulsions are difficult to generate consistently due to person-to-person variations
- Throughput: traditional methods are time consuming and only allow to produce one emulsion at the time
- Cost efficiency: due to important dead volume, a large quantity of drugs can be lost.
In order to overcome these difficulties, BTB Emulsions has developed a device and method to be used on Precellys homogenizers named POWER-Kit™. This combination ensures the generation of several high-quality emulsions in a consistent way.
