Cyclooxygenase-1, not cyclooxygenase-2, is responsible for physiological production of prostacyclin in the cardiovascular system

Nicholas S. Kirkbya,b,1, Martina H. Lundberga,b,1, Louise S. Harringtona,1, Philip D. M. Leadbeatera, Ginger L. Milnec, Claire M. F. Pottera, Malak Al-Yamania,d, Oladipupo Adeyemia, Timothy D. Warnerb,2, and Jane A. Mitchella,e,2,3

Sources: aCardiothoracic Pharmacology,, National Heart and Lung Institute, Imperial College, London SW3 6LY, United Kingdom; bThe William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, London EC1M 6BQ, United Kingdom; cDepartments of Pharmacology, and Medicine, Vanderbilt University, Nashville, TN 37232; dKing Fahad Cardiac Center, King Saud University, Riyadh 11472, Saudi Arabia; and eInstitute of Cardiovascular Medicine (ICMS), London SW3 6NP, United Kingdom

Edited by Philip Needleman, Washington University School of Medicine, Creve Coeur, MO, and approved September 10, 2012 (received for review June 2, 2012), www.pnas.org/cgi/doi/10.1073/pnas.1209192109