[PRECELLYS] Protein extraction from human blood conduits with Minilys

Up to 50% of saphenous vein (SV) grafts will be occluded ten years after a coronary bypass operation, compared to only 2-5% of the mammary (IMA) or radial (RA) artery grafts. The superior patency of the arterial graft translates into improved long-term survival and freedom from cardiac-related adverse events. SV graft occlusion after bypass surgery is primarily related to accelerated graft atherosclerosis. The superiority of arterial grafts compared to SVs has been attributed to their striking resistance to atherosclerosis. In this study, we evaluated one of the primary protective cellular mechanisms against oxidative stress and atherosclerosis, Thioredoxin-1 (Trx-1) in arterial and venous conduits.