Teleost Fish Mount Complex Clonal IgM and IgT Responses in Spleen upon Systemic Viral Infection

Rosario Castro1, Luc Jouneau1, Hang-Phuong Pham2, Olivier Bouchez3, Ve´ronique Giudicelli4, Marie-Paule Lefranc4, Edwige Quillet5, Abdenour Benmansour1, Fre´de´ ric Cazals6, Adrien Six2, Simon Fillatreau7, Oriol Sunyer8, Pierre Boudinot1*

Sources: 1 Virologie et Immunologie Moléculaires, INRA, Jouy-en-Josas, France, 2 UPMC Univ Paris 06, UMR 7211, ‘‘Integrative Immunology’’ Team, Paris, France; CNRS, UMR 7211, ‘‘Immunology, Immunopathology, Immunotherapy,’’ Paris, France, 3 UMR INRA 0444 Laboratoire de Génétique Cellulaire, GeT-PlaGe Core Facility, Castanet Tolosan, France, 4 IMGT, the International ImMunoGeneTics Information System, Laboratoire d’ImmunoGénétique Moléculaire LIGM, IGH, UPR CNRS 1142 and Université Montpellier 2, Montpellier, France, 5 Génétique Animale et Biologie Intégrative, INRA, Jouy-en-Josas, France, 6 INRIA Sophia-Antipolis - Méditerranée, Algorithms-Biology- Structure, Sophia-Antipolis, France, 7 Deutsches RheumaForschungszentrum, a Leibniz Institute, Berlin, Germany, 8 Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

PLoS Pathog 9(1): e1003098. doi:10.1371/journal.ppat.1003098, Received April 10, 2012; Accepted November 9, 2012; Published January 10, 2013