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TR-FRET-Based Duplex Immunoassay Reveals an Inverse Correlation of Soluble and Aggregated Mutant huntingtin in Huntington’s Disease - Bertin Technologies

TR-FRET-Based Duplex Immunoassay Reveals an Inverse Correlation of Soluble and Aggregated Mutant huntingtin in Huntington’s Disease

Barbara Baldo1, 4, Paolo Paganetti1, 4, 5, Stephan Grueninger1, David Marcellin1, Linda S. Kaltenbach2, Donald C. Lo2, Martin Semmelroth1, Andjelija Zivanovic1, Dorothée Abramowski1, Donna Smith3, Gregor P. Lotz1, Gillian P. Bates3, Andreas Weiss1,

Sources: 1 Neuroscience Discovery, Novartis Institutes for BioMedical Research, Basel CH-4002, Switzerland 2 Center for Drug Discovery and Department of Neurobiology, Duke University Medical Center, Durham, NC 27705, USA 3 Department of Medical and Molecular Genetics, King's College London, London SE1 8WA, UK

Chemistry & Biology Volume 19, Issue 2, 24 February 2012, Pages 264-275 Received 28 July 2011. Revised 22 November 2011. Accepted 8 December 2011. Available online 23 February 2012. Published: February 23, 2012. http://dx.doi.org/10.1016/j.chembiol.2011.12.020

Sample name

Animal tissues (mice brain)

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